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KMID : 0363620150360040042
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Journal of Korean Oriental Medicine
2015 Volume.36 No. 4 p.42 ~ p.55
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Protective Effects of BK-1202 on the Indomethacin-induced Gastric Ulcer in Rats
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Kwon Hae-Won
Kim Dae-Jun
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Abstract
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Purpose: The object of this study is to observe the anti-ulcerative effects of BK-1202 (IGM), a mixed herbal formula consisting of 9 herbal drugs, which have been traditional Korean medicine for treating various digestive diseases, on indomethacin-induced gastric ulcer in rat.
Methods: Three different doses of IGM extract (200, 100 and 50 mg/kg) were orally administered once 30 min before indomethacin treatment. Six hours after indomethacin treatment, changes in the gross lesion scores, fundic histopathology, MPO activity and antioxidant activities were observed. The results were compared with two reference groups treated with omeprazole (10 mg/kg), antioxidant and proton pump inhibitor, and DA-9601 (100 mg/kg), a standardized extract of the herb Artemisiaasiatica.
Results: In all three doses of IGM extract, significantly decreased gastric damages were observed in the indomethacin-induced gastric ulcer rats, when compared with the indomethacin-treated control rats. IGM extracts also strengthened the antioxidative defense systems, decreasing the level of lipid peroxidation and catalase activity while increasing the superoxide dismutase and glutathione contents. IGM extracts showed similar anti-ulcerative effects to those shown by equal dose of DA-9601, and the effects of 50 mg/kg IGM extracts were comparable to those of 10 mg/kg omeprazole.
Conclusion: The results obtained in this study suggest that IGM extract has favorable effects on the indomethacin-induced gastric damages by strengthening the antioxidative defense systems and enhancing anti-inflammatory effects.
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KEYWORD
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BK-1202, Indomethacin, Gastric ulcer
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